FIRMS UP THE SKIN

30%
Improves skin elasticity by up to 30% after just 4 weeks*

REDUCES WRINKLES

50%
Reduces wrinkle volume by up to 50% after just 8 weeks**

MAINTAINS SKIN COLLAGEN BALANCE

65%
Increases skin procollagen levels by up to 65% after just 8 weeks**
SCIENTIFIC BREAKTHROUGH

Scientific documentation from recent clinical studies has greatly increased our knowledge of how we can most effectively protect the appearance of our skin by adopting a sensible diet and nutrition.

These studies that have recently been published in Skin Pharmacology and Physiology, an internationally well-reputed medical journal, show that the intake of specific collagen peptides has a significant positive effect on skin elasticity*, wrinkle volume** and procollagen levels**.

The collagen peptides investigated in the studies were produced using a special biotechnological process where natural, long-chain collagen is enzymatically hydrolysed into predefined short peptide chains with specific amino acid sequence, making them totally different from unrefined collagen peptides.

CLINICAL STUDY RESULTS:

SIGNIFICANT INCREASE IN SKIN ELASTICITY

30%
Improves skin elasticity by up to 30% after just 4 weeks*

SIGNIFICANT WRINKLE REDUCTION

50%
Reduces wrinkle volume by up to 50% after just 8 weeks**

SIGNIFICANT INCREASE IN SKIN PROCOLLAGEN LEVELS

65%
Increases skin procollagen levels by up to 65% after just 8 weeks**

The studies were carried out to the highest quality standards. They are randomised, double-blind, placebo-controlled (RDBPC) human observational studies conducted according to the strictest Good Clinical Practice (GCP) standards.

These recent studies, together with previous scientific studies, have shown that collagen peptides only reaches the cells of the deeper layers of the skin optimally when they are produced by a unique method that ensures their effectiveness. These collagen peptides are produced using a special biotechnological process where natural, long-chain collagen is enzymatically hydrolysed into predefined short peptide chains having specific amino acid sequence.

* Daily intake of specific collagen peptides in a double-blind, randomised, placebo-controlled observational study of 69 people showed significant improvement in skin elasticity after 4 weeks, in some cases by up to 30%.
[1] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacol Physiol 2014; 27:47-55.
** Daily intake of specific collagen peptides in a double-blind, randomised, placebo-controlled observational study of 114 people showed significant
reductions in eye wrinkle volume after 8 weeks, in some cases by up to 50%. The same clinical study shows a significant (65%) increase in procollagen
levels in the skin after 8 weeks.
[2] Proksch E, et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol 2014; 27:113–119.

IMPROVED SKIN ELASTICITY IN WOMEN (50+):

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SCIENTIFIC BACKGROUND

These significant results from the double-blind, randomised, placebo-controlled observational studies are enggrafadditionally supported by a number of previous in-vitro and in-vivo pre-clinical and clinical studies.

Studies have shown that collagen peptides are rapidly absorbed by the body in their natural peptide form[3],[4] and then transported to the skin[5] via the bloodstream[6],[7],[8],[9]. Studies also shown that collagen peptides may influence the production of the skin’s own collagen-producing cells, called fibroblasts[10],[11],[12], thereby stimulating increased turnover of collagen[2],[13],[14],[15],[16],[17] and other connective tissue components. Finally, scientific studies show that the intake of collagen peptides has a significant effect on the epidermis and dermis in the form of greater moisture balance[18],[19],[20], wrinkle reduction[2],[21],[22],[23] and improved elasticity[1],[18],[24].

[1] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacol Physiol 2014; 27:47-55.
[2] Proksch E, et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol 2014; 27:113–119.
[3] Oesser S, et al. Oral administration of 14C-labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage in mice (C57/BL). J Nutr 1999;129:1891-1895.
[4] Zague V. A new view concerning the effects of collagen hydrolysate on skin properties. Arch Dermatol Res 2008; 300:479-483.
[5] Kawaguchi T, et al. Distribution of prolylhydroxyproline and its metabolites after oral administration in rats. Biol Pharm Bull 2012;35(3):422-427.
[6] Ohara H, et al. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J Agric Food Chem 2007;55:1532-1535.
[7] Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem 2005;53:6531-6536.
[8] Ichikawa S, et al. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Inter J Food Sci Nutr 2010;61(1):52-60.
[9] Watanabe-Kamiyama M, et al. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem 2010;58(2):835-841.
[10] Shigemura Y, et al. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem 2009;57:444-449.
[11] Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol 2010;37(4):330-338.
[12] Postlethwaite AE, et al. Chemotactic attraction of human fibroblasts to type I, II and III collagen and collagen-derived peptides. Proc Acad Sci USA 1978;75:871-875.
[13] Rousselot SAS, unpublished data, 2012, Clinical study, Cosderma, France.
[14] Matsuda N, et al. Effects on ingestion of collagen peptide on collagen fibrils and glucosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo) 2006;52:211-215.
[15] Tanaka M, et al. Effects of collagen peptide ingestion on UVB-induced skin damage. Biosci Biotechnol Biochem 2009;73:930-932.
[16] Zague V, et al. Collagen hydrolysate intake increases skin collagen expression and suppress matrix collagenase 2 activity. J Med Food 2011;14:618-624.
[17] Minaguchi J, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol (Tokyo) 2005;51:169-174.
[18] Kikuchi K, Matahira Y. Efficacy of orally-ingested marine collagen peptide on dryness and roughness of the human skin. Fragrance Journal 2003;9:97-102.
[19] Rousselot SAS, unpublished data, 2008, Clinical study, Souken, Japan.
[20] Shimizu J, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun 2015;456(2):626-630.
[21] Pyun HB, et al. Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Prev Nutr Sci 2012;17(4):245-253.
[22] Borumand M, Sibilla S. Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. J Med Nutr Nutraceut 2015;4:47-53.
[23] Rousselot SAS, unpublished data, 2008, Clinical study, Dermscan, France.
[24] Oba C, et al. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatol Photoimmunol Photomed 2013;29(4):204-211.